Review on Cns Activity of Isatin Derivatives

Isatin derivatives are one of most potent anticonvulsant agent of natural origin. It has display potent anticonvulsant effect in a wide variety of preclinical anticonvulsant models. Till date various isatin derivatives have been synthesized and evaluated for anticonvulsant activity. This review is an attempt to compile the medicinal chemistry of various synthesized isatin analogs. Isatin and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Isatin and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different, biological activities. In the past few decades, Isatin and its derivatives have received much attention due to their chemotherapeutic values. This review covers updated information on the most active isatin derivatives that have been reported to show considerable pharmacological actions such as, anticonvulsant, antianixity and antipsychoactives activity. From these results, ideas for future molecular modifications leading to compounds with greater favorable pharmacological properties may be derived. Keyword: Isatin derivatives, Anticonvulsant, Structure-activity relationship.